While the vaccines both use mRNA technology, they are not identical. Mark Fierstein, internal medicine specialist at NYU Langone Ambulatory Care Lake Success, told Healthline. This is why I would contend that it is more important to get vaccinated than to worry about which vaccine you are receiving,” Dr. “Clearly, the differences between the vaccines get even smaller as we consider the more serious outcomes. For deaths, the Pfizer-BioNTech vaccine recipients had 0.02 excess events for every 1,000 people.For ICU cases, the difference dropped to 0.10 excess cases per 1,000 people.For hospitalizations, the Pfizer-BioNTech group had 0.55 excess cases per 1,000 people.The differences between the two vaccines remained consistently small for severity of disease: He said the vaccines are so similar that he wouldn’t be surprised if another head-to-head comparison in another population “turned this upside down because the differences really are very, very small.” ![]() “It’s great that we have two excellent vaccines.” It’s like two baseball players hitting home runs, but one of the home runs got a little bit higher in the seats than the other,” said Schaffner. “You stand back a little and you can’t see that difference. This resulted in an excess of 1.23 cases of documented infection per 1,000 people in the Pfizer-BioNTech group. The percentages are derived from the estimated risk of documented (asymptomatic) infection being 4.52 events per 1,000 people in the Moderna vaccine group and 5.75 events per 1,000 people in the Pfizer-BioNTech group. William Schaffner, professor of preventive medicine and infectious diseases at Vanderbilt University Medical Center in Nashville, told Healthline. They already start out very small, so it’s like the difference of 94 percent and 92 percent,” Dr. “That looks like a big number, but look at the two numbers they’re comparing. However, Moderna showed a slight edge by offering an increased level of protection, including a 21 percent lower risk of documented infection and 41 percent lower risk of hospitalization. The results show that both vaccines are significantly effective. Dickerman, first author of the study, told Healthline.Įffectiveness of the vaccines was measured based on: We also knew that detecting any subtle differences between their effectiveness would require a head-to-head comparison in a very large sample - much larger than would be practical in a randomized trial,” Dr. “We knew from early randomized trials that the Pfizer-BioNTech and Moderna vaccines were both remarkably effective at preventing symptomatic disease. Chan School of Public Health, and Brigham and Women’s Hospital teamed up to analyze electronic health records of nearly 220,000 veterans who received two doses of the Moderna vaccine and about 220,000 veterans who received two doses of the Pfizer-BioNTech vaccine. Researchers from the Department of Veterans Affairs, Harvard T.H. Now, the first head-to-head comparison of the Pfizer-BioNTech and Moderna vaccines has been released. Since the Food and Drug Administration (FDA) approved emergency use of COVID-19 vaccines, many people have wondered whether one vaccine is better than the other. ![]()
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